Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Sirtuins are a highly conserved class of NAD(+)-dependent lysine deacylases. The human isotype Sirt2 has been implicated in the pathogenesis of cancer, inflammation and neurodegeneration, which makes the modulation of Sirt2 activity a promising strategy for pharmaceutical intervention. A rational ba...

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Detalles Bibliográficos
Autores principales: Rumpf, Tobias, Schiedel, Matthias, Karaman, Berin, Roessler, Claudia, North, Brian J., Lehotzky, Attila, Oláh, Judit, Ladwein, Kathrin I., Schmidtkunz, Karin, Gajer, Markus, Pannek, Martin, Steegborn, Clemens, Sinclair, David A., Gerhardt, Stefan, Ovádi, Judit, Schutkowski, Mike, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339887/
https://www.ncbi.nlm.nih.gov/pubmed/25672491
http://dx.doi.org/10.1038/ncomms7263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339887/
https://www.ncbi.nlm.nih.gov/pubmed/25672491
http://dx.doi.org/10.1038/ncomms7263

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