Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

Understanding the emerging models of adaptive resistance is key to overcoming cancer chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo studies and mathematical modelling, here we show that exposure to a taxane induces phenotypic cell state transition toward...

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Detalles Bibliográficos
Autores principales: Goldman, Aaron, Majumder, Biswanath, Dhawan, Andrew, Ravi, Sudharshan, Goldman, David, Kohandel, Mohammad, Majumder, Pradip K., Sengupta, Shiladitya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339891/
https://www.ncbi.nlm.nih.gov/pubmed/25669750
http://dx.doi.org/10.1038/ncomms7139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339891/
https://www.ncbi.nlm.nih.gov/pubmed/25669750
http://dx.doi.org/10.1038/ncomms7139

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