High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs

Neuroguidin (NGDN) is a eukaryotic translation initiation factor 4E binding protein. The purpose of this study was to clarify the function of NGDN and its possible mechanism of action in human myeloid leukemia cells. Proliferation inhibition and apoptosis in NGDN over-expressing myeloid multidrug-re...

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Autores principales: Chen, Kejun, Lü, Shuqing, Cheng, Hui, Tang, Gusheng, Liu, Min, Zhou, Hong, Wang, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340276/
https://www.ncbi.nlm.nih.gov/pubmed/25887473
http://dx.doi.org/10.1186/s13045-015-0108-6
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author Chen, Kejun
Lü, Shuqing
Cheng, Hui
Tang, Gusheng
Liu, Min
Zhou, Hong
Wang, Jianmin
author_facet Chen, Kejun
Lü, Shuqing
Cheng, Hui
Tang, Gusheng
Liu, Min
Zhou, Hong
Wang, Jianmin
author_sort Chen, Kejun
collection PubMed
description Neuroguidin (NGDN) is a eukaryotic translation initiation factor 4E binding protein. The purpose of this study was to clarify the function of NGDN and its possible mechanism of action in human myeloid leukemia cells. Proliferation inhibition and apoptosis in NGDN over-expressing myeloid multidrug-resistant leukemia cells (K562/A02-NGDN) was significantly higher than in control K562/A02 cells following treatment with vincristine, etoposide, and epirubicin, indicating that NGDN over-expression can increase the sensitivity of multidrug-resistant leukemia cells to chemotherapeutic drugs. Furthermore, NGDN knock-down in K562/A02 cells resulted in the activation of multiple tumor-related signaling pathways, especially the mammalian target of rapamycin (mTOR) pathway. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-015-0108-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-43402762015-02-26 High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs Chen, Kejun Lü, Shuqing Cheng, Hui Tang, Gusheng Liu, Min Zhou, Hong Wang, Jianmin J Hematol Oncol Letter to the Editor Neuroguidin (NGDN) is a eukaryotic translation initiation factor 4E binding protein. The purpose of this study was to clarify the function of NGDN and its possible mechanism of action in human myeloid leukemia cells. Proliferation inhibition and apoptosis in NGDN over-expressing myeloid multidrug-resistant leukemia cells (K562/A02-NGDN) was significantly higher than in control K562/A02 cells following treatment with vincristine, etoposide, and epirubicin, indicating that NGDN over-expression can increase the sensitivity of multidrug-resistant leukemia cells to chemotherapeutic drugs. Furthermore, NGDN knock-down in K562/A02 cells resulted in the activation of multiple tumor-related signaling pathways, especially the mammalian target of rapamycin (mTOR) pathway. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-015-0108-6) contains supplementary material, which is available to authorized users. BioMed Central 2015-02-19 /pmc/articles/PMC4340276/ /pubmed/25887473 http://dx.doi.org/10.1186/s13045-015-0108-6 Text en © Chen et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Chen, Kejun
Lü, Shuqing
Cheng, Hui
Tang, Gusheng
Liu, Min
Zhou, Hong
Wang, Jianmin
High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs
title High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs
title_full High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs
title_fullStr High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs
title_full_unstemmed High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs
title_short High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs
title_sort high expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340276/
https://www.ncbi.nlm.nih.gov/pubmed/25887473
http://dx.doi.org/10.1186/s13045-015-0108-6
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