Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

[Image: see text] Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is not fully rescued by exogenous serine, suggesting p...

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Detalles Bibliográficos
Autores principales: Fan, Jing, Teng, Xin, Liu, Ling, Mattaini, Katherine R., Looper, Ryan E., Vander Heiden, Matthew G., Rabinowitz, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340346/
https://www.ncbi.nlm.nih.gov/pubmed/25406093
http://dx.doi.org/10.1021/cb500683c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340346/
https://www.ncbi.nlm.nih.gov/pubmed/25406093
http://dx.doi.org/10.1021/cb500683c

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