Cargando…

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

[Image: see text] Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is not fully rescued by exogenous serine, suggesting p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Jing, Teng, Xin, Liu, Ling, Mattaini, Katherine R., Looper, Ryan E., Vander Heiden, Matthew G., Rabinowitz, Joshua D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340346/ https://www.ncbi.nlm.nih.gov/pubmed/25406093 http://dx.doi.org/10.1021/cb500683c

Ejemplares similares

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate and promotes histone methylation
por: Fan, Jing, et al.
Publicado: (2014)

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation
por: Mattaini, Katherine R, et al.
Publicado: (2015)

Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite
por: Berger, Raffaela S., et al.
Publicado: (2021)

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis
por: Wang, Tian-Xiang, et al.
Publicado: (2019)

Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis
por: Pickard, Amanda J., et al.
Publicado: (2016)

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
por: Carbonneau, Mélissa, et al.
Publicado: (2016)

The Emerging Role of D-2-Hydroxyglutarate as an Oncometabolite in Hematolymphoid and Central Nervous System Neoplasms
por: Rakheja, Dinesh, et al.
Publicado: (2013)

The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites
por: Hariharan, Vivek A., et al.
Publicado: (2017)

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
por: Locasale, Jason W, et al.
Publicado: (2012)

Another small molecule in the oncometabolite mix: L-2-Hydroxyglutarate in kidney cancer
por: Shim, Eun-Hee, et al.
Publicado: (2015)

D-3-Phosphoglycerate Dehydrogenase
por: Grant, Gregory A.
Publicado: (2018)

Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia
por: Zhu, Xinting, et al.
Publicado: (2023)

Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases
por: Janke, Ryan, et al.
Publicado: (2017)

The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo
por: Suijker, Johnny, et al.
Publicado: (2015)

Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
por: Evans, Brad, et al.
Publicado: (2015)

Imaging 2-hydroxyglutarate and other brain oncometabolites pertinent to critical genomic alterations in brain tumors
por: Thomas, Teena, et al.
Publicado: (2023)

The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer
por: Zhao, Xiaoya, et al.
Publicado: (2020)

Metabolomic analysis identifies differentially produced oral metabolites, including the oncometabolite 2-hydroxyglutarate, in patients with head and neck squamous cell carcinoma
por: Mukherjee, Pranab K., et al.
Publicado: (2016)

The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation
por: Liu, Lizhen, et al.
Publicado: (2021)

Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity
por: Xiang, Kexu, et al.
Publicado: (2022)

Targeting phosphoglycerate dehydrogenase in multiple myeloma
por: Elsaadi, Samah, et al.
Publicado: (2021)

Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations
por: Berger, Raffaela S., et al.
Publicado: (2019)

Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors
por: Zhao, Yue, et al.
Publicado: (2020)

The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas
por: Mu, Luyan, et al.
Publicado: (2018)

Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells
por: Hujber, Zoltán, et al.
Publicado: (2017)

A Drosophila model of combined D-2- and L-2-hydroxyglutaric aciduria reveals a mechanism linking mitochondrial citrate export with oncometabolite accumulation
por: Li, Hongde, et al.
Publicado: (2018)

The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells
por: Chen, Jing-Yi, et al.
Publicado: (2016)

Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney
por: Brinkley, Garrett, et al.
Publicado: (2020)

Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency
por: Tabatabaie, L., et al.
Publicado: (2010)

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth
por: Chen, Jinyun, et al.
Publicado: (2013)

The importance of serine metabolism in cancer
por: Mattaini, Katherine R., et al.
Publicado: (2016)

Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells
por: Li, Luyuan, et al.
Publicado: (2015)

Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation
por: Taub, Mary, et al.
Publicado: (2022)

Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene
por: Zogg, Cheryl K.
Publicado: (2014)

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
por: Mullarky, Edouard, et al.
Publicado: (2016)

Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells
por: Wang, Han, et al.
Publicado: (2022)

Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase
por: Murtas, Giulia, et al.
Publicado: (2021)

Designing Cyclic-Constrained Peptides to Inhibit Human Phosphoglycerate Dehydrogenase
por: Qing, Xiaoyu, et al.
Publicado: (2023)

Oncometabolites and the response to radiotherapy
por: Xiang, Kexu, et al.
Publicado: (2020)

D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma
por: Pusch, Stefan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_tfgbp8gvm2vlfvmpptm5buvuv7