Inhibition of CDC25B Phosphatase Through Disruption of Protein–Protein Interaction

[Image: see text] CDC25 phosphatases are key cell cycle regulators and represent very attractive but challenging targets for anticancer drug discovery. Here, we explored whether fragment-based screening represents a valid approach to identify inhibitors of CDC25B. This resulted in identification of...

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Detalles Bibliográficos
Autores principales: Lund, George, Dudkin, Sergii, Borkin, Dmitry, Ni, Wendi, Grembecka, Jolanta, Cierpicki, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340349/
https://www.ncbi.nlm.nih.gov/pubmed/25423142
http://dx.doi.org/10.1021/cb500883h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340349/
https://www.ncbi.nlm.nih.gov/pubmed/25423142
http://dx.doi.org/10.1021/cb500883h

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