Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

[Image: see text] Aminopyrazoles are a new class of antimalarial compounds identified in a cellular antiparasitic screen with potent activity against Plasmodium falciparum asexual and sexual stage parasites. To investigate their unknown mechanism of action and thus identify their target, we cultured...

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Detalles Bibliográficos
Autores principales: Flannery, Erika L., McNamara, Case W., Kim, Sang Wan, Kato, Tomoyo Sakata, Li, Fengwu, Teng, Christine H., Gagaring, Kerstin, Manary, Micah J., Barboa, Rachel, Meister, Stephan, Kuhen, Kelli, Vinetz, Joseph M., Chatterjee, Arnab K., Winzeler, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340351/
https://www.ncbi.nlm.nih.gov/pubmed/25322084
http://dx.doi.org/10.1021/cb500616x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340351/
https://www.ncbi.nlm.nih.gov/pubmed/25322084
http://dx.doi.org/10.1021/cb500616x

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