Cargando…

Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

[Image: see text] Aminopyrazoles are a new class of antimalarial compounds identified in a cellular antiparasitic screen with potent activity against Plasmodium falciparum asexual and sexual stage parasites. To investigate their unknown mechanism of action and thus identify their target, we cultured...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flannery, Erika L., McNamara, Case W., Kim, Sang Wan, Kato, Tomoyo Sakata, Li, Fengwu, Teng, Christine H., Gagaring, Kerstin, Manary, Micah J., Barboa, Rachel, Meister, Stephan, Kuhen, Kelli, Vinetz, Joseph M., Chatterjee, Arnab K., Winzeler, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340351/ https://www.ncbi.nlm.nih.gov/pubmed/25322084 http://dx.doi.org/10.1021/cb500616x

Ejemplares similares

Na(+) Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
por: Spillman, Natalie J., et al.
Publicado: (2013)

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4
por: Ashton, Trent D., et al.
Publicado: (2023)

Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor
por: Goldgof, Gregory M., et al.
Publicado: (2016)

The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs
por: Spillman, Natalie Jane, et al.
Publicado: (2015)

Mechanistic Study of the Spiroindolones: A New Class of Antimalarials
por: Zou, Bin, et al.
Publicado: (2012)

Drug resistance genomics of the antimalarial drug artemisinin
por: Winzeler, Elizabeth A, et al.
Publicado: (2014)

Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach
por: N., Nagasundaram, et al.
Publicado: (2016)

Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors
por: Tewari, Shivendra G., et al.
Publicado: (2023)

Status of potential PfATP6 molecular markers for artemisinin resistance in Suriname
por: Adhin, Malti R, et al.
Publicado: (2012)

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4
por: Gilson, Paul R., et al.
Publicado: (2019)

Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates
por: Woodrow, Charles J, et al.
Publicado: (2012)

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria
por: Yeung, Bryan K. S., et al.
Publicado: (2010)

A G358S mutation in the Plasmodium falciparum Na(+) pump PfATP4 confers clinically-relevant resistance to cipargamin
por: Qiu, Deyun, et al.
Publicado: (2022)

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections
por: Pillai, Dylan R, et al.
Publicado: (2012)

PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion
por: Barnes, Claudia B. G., et al.
Publicado: (2022)

Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity
por: Burgart, Yanina V., et al.
Publicado: (2022)

Cell-based optimization of novel benzamides as potential antimalarial leads
por: Wu, Tao, et al.
Publicado: (2009)

Approaches towards the synthesis of 5-aminopyrazoles
por: Aggarwal, Ranjana, et al.
Publicado: (2011)

Purified E255L Mutant SERCA1a and Purified PfATP6 Are Sensitive to SERCA-type Inhibitors but Insensitive to Artemisinins
por: Cardi, Delphine, et al.
Publicado: (2010)

Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives
por: Medrasi, Hanadi Y., et al.
Publicado: (2013)

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission
por: Plouffe, David M., et al.
Publicado: (2016)

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents
por: Nagle, Advait, et al.
Publicado: (2012)

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission
por: Kuhen, Kelli L., et al.
Publicado: (2014)

Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents
por: Huang, Jian, et al.
Publicado: (2021)

5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines
por: Aggarwal, Ranjana, et al.
Publicado: (2018)

Cyanothioacetamides as a synthetic platform for the synthesis of aminopyrazole derivatives
por: Filimonov, Valeriy O, et al.
Publicado: (2023)

One-Flask Synthesis of Pyrazolo[3,4-d]pyrimidines from 5-Aminopyrazoles and Mechanistic Study
por: Yen, Wan-Ping, et al.
Publicado: (2017)

New one-pot synthesis of 4-arylpyrazolo[3,4-b]pyridin-6-ones based on 5-aminopyrazoles and azlactones
por: Shuvalov, Vladislav Yu, et al.
Publicado: (2023)

Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents
por: Wu, Tao, et al.
Publicado: (2011)

Antileishmanial Aminopyrazoles: Studies into Mechanisms and Stability of Experimental Drug Resistance
por: Van den Kerkhof, M., et al.
Publicado: (2020)

Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malaria
por: McNamara, Case W, et al.
Publicado: (2013)

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1
por: Huang, Wenlin, et al.
Publicado: (2015)

Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model
por: Lakshminarayana, Suresh B., et al.
Publicado: (2015)

Spiroindolone Analogues as Potential Hypoglycemic with Dual Inhibitory Activity on α-Amylase and α-Glucosidase
por: Altowyan, Mezna Saleh, et al.
Publicado: (2019)

Pfatp6 molecular profile of Plasmodium falciparum isolates in the western Brazilian Amazon
por: Brasil, Larissa W, et al.
Publicado: (2012)

Discovery of Small-Molecule Allosteric Inhibitors of PfATC as Antimalarials
por: Wang, Chao, et al.
Publicado: (2022)

Genetic validation of PfFKBP35 as an antimalarial drug target
por: Thommen, Basil T, et al.
Publicado: (2023)

Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis
por: Van Bocxlaer, Katrien, et al.
Publicado: (2019)

Antimalarial Peptide and Polyketide Natural Products from the Fijian Marine Cyanobacterium Moorea producens
por: Sweeney-Jones, Anne Marie, et al.
Publicado: (2020)

A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609
por: Zhang, Rou, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1f6enov2ithb2a121q3dd0jm2u