Anticancer/Antiviral Agent Akt Inhibitor-IV Massively Accumulates in Mitochondria and Potently Disrupts Cellular Bioenergetics

[Image: see text] Inhibitors of the PI3-kinase/Akt (protein kinase B) pathway are under investigation as anticancer and antiviral agents. Akt inhibitor-IV (ChemBridge 5233705, CAS 681281-88-9, AKTIV), a small molecule reported to inhibit this pathway, exhibits potent anticancer and broad-spectrum an...

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Detalles Bibliográficos
Autores principales: Meinig, J. Matthew, Peterson, Blake R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340353/
https://www.ncbi.nlm.nih.gov/pubmed/25415586
http://dx.doi.org/10.1021/cb500856c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340353/
https://www.ncbi.nlm.nih.gov/pubmed/25415586
http://dx.doi.org/10.1021/cb500856c

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