Cardiac Glycoside Activities Link Na(+)/K(+) ATPase Ion-Transport to Breast Cancer Cell Migration via Correlative SAR

[Image: see text] The cardiac glycosides ouabain and digitoxin, established Na(+)/K(+) ATPase inhibitors, were found to inhibit MDA-MB-231 breast cancer cell migration through an unbiased chemical genetics screen for cell motility. The Na(+)/K(+) ATPase acts both as an ion-transporter and as a recep...

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Detalles Bibliográficos
Autores principales: Magpusao, Anniefer N., Omolloh, George, Johnson, Joshua, Gascón, José, Peczuh, Mark W., Fenteany, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340362/
https://www.ncbi.nlm.nih.gov/pubmed/25334087
http://dx.doi.org/10.1021/cb500665r

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340362/
https://www.ncbi.nlm.nih.gov/pubmed/25334087
http://dx.doi.org/10.1021/cb500665r

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