Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury

BACKGROUND: T cells have been implicated in neuropathic pain that is caused by peripheral nerve injury. Immunogenic myelin basic protein (MBP) peptides have been shown to initiate mechanical allodynia in a T cell-dependent manner. Antagonistic altered peptide ligands (APLs) are peptides with substit...

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Detalles Bibliográficos
Autores principales: Perera, Chamini J, Duffy, Samuel S, Lees, Justin G, Kim, Cristina F, Cameron, Barbara, Apostolopoulos, Vasso, Moalem-Taylor, Gila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340611/
https://www.ncbi.nlm.nih.gov/pubmed/25885812
http://dx.doi.org/10.1186/s12974-015-0253-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340611/
https://www.ncbi.nlm.nih.gov/pubmed/25885812
http://dx.doi.org/10.1186/s12974-015-0253-4

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