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Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury

BACKGROUND: T cells have been implicated in neuropathic pain that is caused by peripheral nerve injury. Immunogenic myelin basic protein (MBP) peptides have been shown to initiate mechanical allodynia in a T cell-dependent manner. Antagonistic altered peptide ligands (APLs) are peptides with substit...

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Detalles Bibliográficos
Autores principales:	Perera, Chamini J, Duffy, Samuel S, Lees, Justin G, Kim, Cristina F, Cameron, Barbara, Apostolopoulos, Vasso, Moalem-Taylor, Gila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340611/ https://www.ncbi.nlm.nih.gov/pubmed/25885812 http://dx.doi.org/10.1186/s12974-015-0253-4

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