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Pharmacokinetic Study of 14-(3-Methylbenzyl)matrine and 14-(4-Methylbenzyl)matrine in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry

A rapid, sensitive and selective high-performance liquid chromatography-tandem mass spectrometric method (HPLC-MS) was developed and validated to determine the 14-(3-methylbenzyl)matrine (3MBM) and 14-(4-methylbenzyl)matrine (4MBM) levels in rat plasma in the present study. The analytes were separat...

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Detalles Bibliográficos
Autores principales: Jiang, Minjie, Wang, Lisheng, Huang, Shulin, Xu, Liba, Hu, Chao, Jiang, Weizhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340794/
https://www.ncbi.nlm.nih.gov/pubmed/25714369
http://dx.doi.org/10.1371/journal.pone.0116010