Fatty Acid Synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death

Blockade of fatty acid synthase (FASN), a key enzyme involved in de novo lipogenesis, results in robust death of ovarian cancer cells. However, known FASN inhibitors have proven to be poor therapeutic agents due to their ability to induce cachexia. Therefore, we sought to identify additional targets...

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Detalles Bibliográficos
Autores principales: Yang, Chih-Sheng, Matsuura, Kenkyo, Huang, Nai-Jia, Robeson, Alexander C., Huang, Bofu, Zhang, Liguo, Kornbluth, Sally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340825/
https://www.ncbi.nlm.nih.gov/pubmed/25151963
http://dx.doi.org/10.1038/onc.2014.271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340825/
https://www.ncbi.nlm.nih.gov/pubmed/25151963
http://dx.doi.org/10.1038/onc.2014.271

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