Anti-Apoptotic NF-κB and “Gain of Function” mutp53 in Concert Act Pro-Apoptotic in Response to UVB+IL-1 via Enhanced TNF Production

In response to genotoxic stress, including UVB radiation, transcription factors NF-κB and p53 inevitably influence the cellular fate. Loss of p53 function has been attributed to malignant transformation and interferes with therapeutic interventions, whereas “gain of function” mutants even enhance tu...

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Detalles Bibliográficos
Autores principales: Müller, Ines, Beissert, Stefan, Kulms, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340977/
https://www.ncbi.nlm.nih.gov/pubmed/25380350
http://dx.doi.org/10.1038/jid.2014.481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340977/
https://www.ncbi.nlm.nih.gov/pubmed/25380350
http://dx.doi.org/10.1038/jid.2014.481

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