High yield purification of full-length functional hERG K(+) channels produced in Saccharomyces cerevisiae

The hERG potassium channel is essential for repolarization of the cardiac action potential. Due to this vital function, absence of unintended and potentially life-threatening interactions with hERG is required for approval of new drugs. The structure of hERG is therefore one of the most sought-after...

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Detalles Bibliográficos
Autores principales: Molbaek, Karen, Scharff-Poulsen, Peter, Helix-Nielsen, Claus, Klaerke, Dan A, Pedersen, Per Amstrup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341239/
https://www.ncbi.nlm.nih.gov/pubmed/25656388
http://dx.doi.org/10.1186/s12934-015-0193-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341239/
https://www.ncbi.nlm.nih.gov/pubmed/25656388
http://dx.doi.org/10.1186/s12934-015-0193-9

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