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High yield purification of full-length functional hERG K(+) channels produced in Saccharomyces cerevisiae
The hERG potassium channel is essential for repolarization of the cardiac action potential. Due to this vital function, absence of unintended and potentially life-threatening interactions with hERG is required for approval of new drugs. The structure of hERG is therefore one of the most sought-after...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341239/ https://www.ncbi.nlm.nih.gov/pubmed/25656388 http://dx.doi.org/10.1186/s12934-015-0193-9 |