Paroxetine engenders analgesic effects through inhibition of p38 phosphorylation in a rat migraine model☆

In this study, a model of migraine was established by electrical stimulation of the superior sagittal sinus in rats. These rats were then treated orally with paroxetine at doses of 2.5, 5, or 10 mg/kg per day for 14 days. Following treatment, mechanical withdrawal thresholds were significantly highe...

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Detalles Bibliográficos
Autores principales: Wang, Chuanming, Bi, Wei, Liang, Yanran, Jing, Xiuna, Xiao, Songhua, Fang, Yannan, Shi, Qiaoyun, Tao, Enxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Brain Injury and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341271/
https://www.ncbi.nlm.nih.gov/pubmed/25722689
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.13.007
Descripción
Sumario:In this study, a model of migraine was established by electrical stimulation of the superior sagittal sinus in rats. These rats were then treated orally with paroxetine at doses of 2.5, 5, or 10 mg/kg per day for 14 days. Following treatment, mechanical withdrawal thresholds were significantly higher, extracellular concentrations of 5-hydroxytryptamine in the periaqueductal grey matter and nucleus reticularis gigantocellularis were higher, and the expression of phosphorylated p38 in the trigeminal nucleus caudalis was lower. Our experimental findings suggest that paroxetine has analgesic effects in a rat migraine model, which are mediated by inhibition of p38 phosphorylation.

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