Cargando…
Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets
Ras pathway signaling is a critical virulence determinant for pathogenic fungi. Localization of Ras to the plasma membrane (PM) is required for Ras network interactions supporting fungal growth and virulence. For example, loss of Aspergillus fumigatus RasA signaling at the PM via inhibition of palmi...
Autores principales: | Abdallah, Qusai Al, Fortwendel, Jarrod R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341556/ https://www.ncbi.nlm.nih.gov/pubmed/25767465 http://dx.doi.org/10.3389/fmicb.2015.00128 |
Ejemplares similares
-
C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus
por: Al Abdallah, Qusai, et al.
Publicado: (2018) -
The Aspergillus fumigatus farnesyltransferase β-subunit, RamA, mediates growth, virulence, and antifungal susceptibility
por: Norton, Tiffany S., et al.
Publicado: (2017) -
A Fungus-Specific Protein Domain Is Essential for RasA-Mediated Morphogenetic Signaling in Aspergillus fumigatus
por: Al Abdallah, Qusai, et al.
Publicado: (2016) -
SH3‐class Ras guanine nucleotide exchange factors are essential for Aspergillus fumigatus invasive growth
por: Martin‐Vicente, Adela, et al.
Publicado: (2019) -
A Simple and Universal System for Gene Manipulation in Aspergillus fumigatus: In Vitro-Assembled Cas9-Guide RNA Ribonucleoproteins Coupled with Microhomology Repair Templates
por: Al Abdallah, Qusai, et al.
Publicado: (2017)