A Study into the Evolutionary Divergence of the Core Promoter Elements of PRPF31 and TFPT

Mutations in PRPF31 have been implicated in retinitis pigmentosa, a blinding disease caused by degeneration of rod photoreceptors. The disease mechanism in the majority of cases is haploinsufficiency. Crucially, attempts at generation of animal models of disease have proved unsuccessful, yielding an...

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Detalles Bibliográficos
Autores principales: Rose, Anna M., Shah, Amna Z., Alfano, Giovanna, Bujakowska, Kinga M., Barker, Amy F., Robertson, J Louis, Rahman, Sufia, Sánchez, Lourdes Valdés, Diaz-Corrales, Francisco J., Chakarova, Christina F., Krishna, Abhay, Bhattacharya, Shomi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341892/
https://www.ncbi.nlm.nih.gov/pubmed/25729402
http://dx.doi.org/10.4172/1747-0862.1000067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341892/
https://www.ncbi.nlm.nih.gov/pubmed/25729402
http://dx.doi.org/10.4172/1747-0862.1000067

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