Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype

Expression of surface NKG2D ligand MIC on tumor cells is deemed to stimulate NK and co-stimulate CD8 T cell anti-tumor immunity. Human cancer cells however frequently adopt a proteinase-mediated shedding strategy to generate soluble MIC (sMIC) to circumvent host immunity. High levels of sMIC have be...

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Detalles Bibliográficos
Autores principales: Xiao, Gang, Wang, Xuanjun, Sheng, Jun, Lu, Shengjun, Yu, Xuezhong, Wu, Jennifer D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342005/
https://www.ncbi.nlm.nih.gov/pubmed/25887583
http://dx.doi.org/10.1186/s13045-015-0110-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342005/
https://www.ncbi.nlm.nih.gov/pubmed/25887583
http://dx.doi.org/10.1186/s13045-015-0110-z

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