GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis

Chemotaxis requires precisely coordinated polymerization and depolymerization of the actin cytoskeleton at leading fronts of migrating cells. However, GPCR activation-controlled F-actin depolymerization remains largely elusive. Here, we reveal a novel signaling pathway, including Gαi, PLC, PKCβ, pro...

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Detalles Bibliográficos
Autores principales: Xu, Xuehua, Gera, Nidhi, Li, Hongyan, Yun, Michelle, Zhang, Liyong, Wang, Youhong, Wang, Q. Jane, Jin, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342024/
https://www.ncbi.nlm.nih.gov/pubmed/25568344
http://dx.doi.org/10.1091/mbc.E14-05-0982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342024/
https://www.ncbi.nlm.nih.gov/pubmed/25568344
http://dx.doi.org/10.1091/mbc.E14-05-0982

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