Cargando…

Arp2/3 complex inhibition radically alters lamellipodial actin architecture, suspended cell shape, and the cell spreading process

Recent studies have investigated the dendritic actin cytoskeleton of the cell edge's lamellipodial (LP) region by experimentally decreasing the activity of the actin filament nucleator and branch former, the Arp2/3 complex. Here we extend these studies via pharmacological inhibition of the Arp2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Henson, John H., Yeterian, Mesrob, Weeks, Richard M., Medrano, Angela E., Brown, Briana L., Geist, Heather L., Pais, Mollyann D., Oldenbourg, Rudolf, Shuster, Charles B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342025/ https://www.ncbi.nlm.nih.gov/pubmed/25568343 http://dx.doi.org/10.1091/mbc.E14-07-1244

Ejemplares similares

Arp2/3 complex ATP hydrolysis promotes lamellipodial actin network disassembly but is dispensable for assembly
por: Ingerman, Elena, et al.
Publicado: (2013)

Lamellipodial actin branches out
por: Short, Ben
Publicado: (2015)

Dynamin2 Organizes Lamellipodial Actin Networks to Orchestrate Lamellar Actomyosin
por: Menon, Manisha, et al.
Publicado: (2014)

A phenomenological density-scaling approach to lamellipodial actin dynamics(†)
por: Lewalle, Alexandre, et al.
Publicado: (2014)

Cell Spreading and Lamellipodial Extension Rate Is Regulated by Membrane Tension
por: Raucher, Drazen, et al.
Publicado: (2000)

GMFβ controls branched actin content and lamellipodial retraction in fibroblasts
por: Haynes, Elizabeth M., et al.
Publicado: (2015)

Directional Transport of a Bead Bound to Lamellipodial Surface Is Driven by Actin Polymerization
por: Nobezawa, Daisuke, et al.
Publicado: (2017)

Rac and Arp2/3-Nucleated Actin Networks Antagonize Rho During Mitotic and Meiotic Cleavages
por: Pal, Debadrita, et al.
Publicado: (2020)

The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner
por: O'Connell, Meghan E., et al.
Publicado: (2019)

Predictive assembling model reveals the self-adaptive elastic properties of lamellipodial actin networks for cell migration
por: Chen, Xindong, et al.
Publicado: (2020)

Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes
por: Rutkowski, David M., et al.
Publicado: (2021)

FMNL formins boost lamellipodial force generation
por: Kage, Frieda, et al.
Publicado: (2017)

Author Correction: Predictive assembling model reveals the self-adaptive elastic properties of lamellipodial actin networks for cell migration
por: Chen, Xindong, et al.
Publicado: (2021)

Actin-Related Protein 2 (ARP2) and Virus-Induced Filopodia Facilitate Human Respiratory Syncytial Virus Spread
por: Mehedi, Masfique, et al.
Publicado: (2016)

Mathematical modeling of Myosin induced bistability of Lamellipodial fragments
por: Hirsch, S., et al.
Publicado: (2016)

The Saccharomyces cerevisiae actin-related protein Arp2 is involved in the actin cytoskeleton
Publicado: (1996)

The Abl-related gene (Arg) requires its F-actin–microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion
por: Miller, Ann L., et al.
Publicado: (2004)

Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments
por: LeClaire, Lawrence L., et al.
Publicado: (2008)

Direct measurement of the lamellipodial protrusive force in a migrating cell
por: Prass, Marcus, et al.
Publicado: (2006)

Arp2/3 complex activity in filopodia of spreading cells
por: Johnston, Simon A, et al.
Publicado: (2008)

Sequences, structural models, and cellular localization of the actin- related proteins Arp2 and Arp3 from Acanthamoeba
Publicado: (1995)

Actin-related protein Arp4 functions in kinetochore assembly
por: Ogiwara, Hideaki, et al.
Publicado: (2007)

Tobacco Arp3 is localized to actin-nucleating sites in vivo
por: Maisch, Jan, et al.
Publicado: (2009)

Structure and functional interactions of INO80 actin/Arp module
por: Zhang, Xuan, et al.
Publicado: (2018)

Growth of neurites without filopodial or lamellipodial activity in the presence of cytochalasin B
Publicado: (1984)

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes
por: Galloni, Chiara, et al.
Publicado: (2021)

The structural basis of actin filament branching by the Arp2/3 complex
por: Rouiller, Isabelle, et al.
Publicado: (2008)

Arp2/3 complex interactions and actin network turnover in lamellipodia
por: Lai, Frank PL, et al.
Publicado: (2008)

Distinct Roles for Arp2/3 Regulators in Actin Assembly and Endocytosis
por: Galletta, Brian J, et al.
Publicado: (2008)

MICAL2 fine-tunes Arp2/3 for actin branching
por: Olson, Michael F., et al.
Publicado: (2021)

Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves
por: Le Chua, Xiang, et al.
Publicado: (2023)

The Actin-Family Protein Arp4 Is a Novel Suppressor for the Formation and Functions of Nuclear F-Actin
por: Yamazaki, Shota, et al.
Publicado: (2020)

Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
por: Braren, Rickmer, et al.
Publicado: (2006)

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase
por: Owen, Katherine A., et al.
Publicado: (2007)

Coactosin-Like 1 Antagonizes Cofilin to Promote Lamellipodial Protrusion at the Immune Synapse
por: Kim, Joanna, et al.
Publicado: (2014)

SOD1 stimulates lamellipodial protrusions in Neuro 2A cell lines
por: Ferrari, Ilaria, et al.
Publicado: (2018)

Buckle up: Membrane tension drives lamellipodial network compression and adhesion deposition
por: Keren, Kinneret, et al.
Publicado: (2017)

Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin
por: Humphries, Christine L., et al.
Publicado: (2002)

New insights into the interaction of cytoplasmic dynein with the actin- related protein, Arp1
Publicado: (1994)

Role of ARP2/3 Complex-Driven Actin Polymerization in RSV Infection
por: Paluck, Autumn, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ral95puj2860hlnf77mkha727e