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Targeting adipose tissue via systemic gene therapy
Adipose tissue plays a critical role in energy and metabolic homeostasis, but it is challenging to adapt techniques to modulate adipose function in vivo. Here we develop an in vivo, systemic method of gene transfer specifically targeting adipose tissue using adeno-associated virus (AAV) vectors. We...
Autores principales: | O'Neill, Sean M., Hinkle, Christine, Chen, Shu-Jen, Sandhu, Arbansjit, Hovhannisyan, Ruben, Stephan, Stephen, Lagor, William R., Ahima, Rexford S., Johnston, Julie C., Reilly, Muredach P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342115/ https://www.ncbi.nlm.nih.gov/pubmed/24830434 http://dx.doi.org/10.1038/gt.2014.38 |
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