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Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

Glucose is the main energy substrate in the adult brain under normal conditions. Accumulating evidence, however, indicates that lactate produced in astrocytes (a type of glial cell) can also fuel neuronal activity. The quantitative aspects of this so-called astrocyte-neuron lactate shuttle (ANLS) ar...

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Detalles Bibliográficos
Autores principales: Jolivet, Renaud, Coggan, Jay S., Allaman, Igor, Magistretti, Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342167/
https://www.ncbi.nlm.nih.gov/pubmed/25719367
http://dx.doi.org/10.1371/journal.pcbi.1004036