Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines

BACKGROUND: Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as...

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Detalles Bibliográficos
Autores principales: Doonachar, Alana, Gallo, Michael D, Doukas, Donald, Pasricha, Rajiv, Lantsberg, Igor, Schoenfeld, Alan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342814/
https://www.ncbi.nlm.nih.gov/pubmed/25729330
http://dx.doi.org/10.1186/s12935-015-0175-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342814/
https://www.ncbi.nlm.nih.gov/pubmed/25729330
http://dx.doi.org/10.1186/s12935-015-0175-3

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