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Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines

BACKGROUND: Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as...

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Detalles Bibliográficos
Autores principales:	Doonachar, Alana, Gallo, Michael D, Doukas, Donald, Pasricha, Rajiv, Lantsberg, Igor, Schoenfeld, Alan R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342814/ https://www.ncbi.nlm.nih.gov/pubmed/25729330 http://dx.doi.org/10.1186/s12935-015-0175-3

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