Ploidy-Seq: inferring mutational chronology by sequencing polyploid tumor subpopulations

Human cancers are frequently polyploid, containing multiple aneuploid subpopulations that differ in total DNA content. In this study we exploit this property to reconstruct evolutionary histories, by assuming that mutational complexity increases with time. We developed an experimental method called...

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Detalles Bibliográficos
Autores principales: Malhotra, Ankit, Wang, Yong, Waters, Jill, Chen, Ken, Meric-Bernstam, Funda, Hall, Ira M, Navin, Nicholas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343275/
https://www.ncbi.nlm.nih.gov/pubmed/25729435
http://dx.doi.org/10.1186/s13073-015-0127-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343275/
https://www.ncbi.nlm.nih.gov/pubmed/25729435
http://dx.doi.org/10.1186/s13073-015-0127-5

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