MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer Cells

We here show a new relationship between the human p14ARF oncosuppressor and the MDM2 oncoprotein. MDM2 overexpression in various cancer cell lines causes p14ARF reduction inducing its degradation through the proteasome. The effect does not require the ubiquitin ligase activity of MDM2 and preferenti...

Descripción completa

Detalles Bibliográficos
Autores principales: Vivo, Maria, Matarese, Maria, Sepe, Maria, Di Martino, Rosaria, Festa, Luisa, Calabrò, Viola, Mantia, Girolama La, Pollice, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344200/
https://www.ncbi.nlm.nih.gov/pubmed/25723571
http://dx.doi.org/10.1371/journal.pone.0117252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344200/
https://www.ncbi.nlm.nih.gov/pubmed/25723571
http://dx.doi.org/10.1371/journal.pone.0117252

Ejemplares similares