In Vitro Metabolic Stability of Exendin-4: Pharmacokinetics and Identification of Cleavage Products

The aim of this study was to investigate the metabolic stability and cleavage sites of exendin-4 in rat tissue homogenates, as well as to identify the types of proteases involved in exendin-4 degradation. The stability of exendin-4 in kidney and liver homogenates from rats was evaluated using liquid...

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Detalles Bibliográficos
Autores principales: Liao, Sha, Liang, Yuanjun, Zhang, Zhiwei, Li, Jinglai, Wang, Juan, Wang, Xiaoying, Dou, Guifang, Zhang, Zhenqing, Liu, Keliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344207/
https://www.ncbi.nlm.nih.gov/pubmed/25723538
http://dx.doi.org/10.1371/journal.pone.0116805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344207/
https://www.ncbi.nlm.nih.gov/pubmed/25723538
http://dx.doi.org/10.1371/journal.pone.0116805

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