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In Vitro Metabolic Stability of Exendin-4: Pharmacokinetics and Identification of Cleavage Products
The aim of this study was to investigate the metabolic stability and cleavage sites of exendin-4 in rat tissue homogenates, as well as to identify the types of proteases involved in exendin-4 degradation. The stability of exendin-4 in kidney and liver homogenates from rats was evaluated using liquid...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344207/ https://www.ncbi.nlm.nih.gov/pubmed/25723538 http://dx.doi.org/10.1371/journal.pone.0116805 |