Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA

Eukaryotic cells carry two genomes, nuclear (nDNA) and mitochondrial (mtDNA), which are ostensibly decoupled in their replication, segregation and inheritance. It is increasingly appreciated that heteroplasmy, the occurrence of multiple mtDNA haplotypes in a cell, plays an important biological role,...

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Detalles Bibliográficos
Autores principales: Jayaprakash, Anitha D., Benson, Erica K., Gone, Swapna, Liang, Raymond, Shim, Jaehee, Lambertini, Luca, Toloue, Masoud M., Wigler, Mike, Aaronson, Stuart A., Sachidanandam, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344500/
https://www.ncbi.nlm.nih.gov/pubmed/25653158
http://dx.doi.org/10.1093/nar/gkv052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344500/
https://www.ncbi.nlm.nih.gov/pubmed/25653158
http://dx.doi.org/10.1093/nar/gkv052

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