Effects of physiological self-crowding of DNA on shape and biological properties of DNA molecules with various levels of supercoiling

DNA in bacterial chromosomes and bacterial plasmids is supercoiled. DNA supercoiling is essential for DNA replication and gene regulation. However, the density of supercoiling in vivo is circa twice smaller than in deproteinized DNA molecules isolated from bacteria. What are then the specific advant...

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Detalles Bibliográficos
Autores principales: Benedetti, Fabrizio, Japaridze, Aleksandre, Dorier, Julien, Racko, Dusan, Kwapich, Robert, Burnier, Yannis, Dietler, Giovanni, Stasiak, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344501/
https://www.ncbi.nlm.nih.gov/pubmed/25653164
http://dx.doi.org/10.1093/nar/gkv055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344501/
https://www.ncbi.nlm.nih.gov/pubmed/25653164
http://dx.doi.org/10.1093/nar/gkv055

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