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Effects of physiological self-crowding of DNA on shape and biological properties of DNA molecules with various levels of supercoiling
DNA in bacterial chromosomes and bacterial plasmids is supercoiled. DNA supercoiling is essential for DNA replication and gene regulation. However, the density of supercoiling in vivo is circa twice smaller than in deproteinized DNA molecules isolated from bacteria. What are then the specific advant...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344501/ https://www.ncbi.nlm.nih.gov/pubmed/25653164 http://dx.doi.org/10.1093/nar/gkv055 |