High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides

The therapeutic use of antisense and siRNA oligonucleotides has been constrained by the limited ability of these membrane-impermeable molecules to reach their intracellular sites of action. We sought to address this problem using small organic molecules to enhance the effects of oligonucleotides by...

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Detalles Bibliográficos
Autores principales: Yang, B., Ming, X., Cao, C., Laing, B., Yuan, A., Porter, M. A., Hull-Ryde, E. A., Maddry, J., Suto, M., Janzen, W. P., Juliano, R. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344505/
https://www.ncbi.nlm.nih.gov/pubmed/25662226
http://dx.doi.org/10.1093/nar/gkv060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344505/
https://www.ncbi.nlm.nih.gov/pubmed/25662226
http://dx.doi.org/10.1093/nar/gkv060

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