Cargando…

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides

The therapeutic use of antisense and siRNA oligonucleotides has been constrained by the limited ability of these membrane-impermeable molecules to reach their intracellular sites of action. We sought to address this problem using small organic molecules to enhance the effects of oligonucleotides by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, B., Ming, X., Cao, C., Laing, B., Yuan, A., Porter, M. A., Hull-Ryde, E. A., Maddry, J., Suto, M., Janzen, W. P., Juliano, R. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344505/ https://www.ncbi.nlm.nih.gov/pubmed/25662226 http://dx.doi.org/10.1093/nar/gkv060

Ejemplares similares

Structure–activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides
por: Juliano, Rudolph L, et al.
Publicado: (2018)

Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung
por: Dang, Yan, et al.
Publicado: (2021)

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice
por: Hagedorn, Peter H, et al.
Publicado: (2018)

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides
por: Anderson, Brooke A, et al.
Publicado: (2021)

Elasticity of the transition state for oligonucleotide hybridization
por: Whitley, Kevin D., et al.
Publicado: (2017)

Modular protein-oligonucleotide signal exchange
por: Agrawal, Deepak K, et al.
Publicado: (2020)

Chemical ligation of oligonucleotides using an electrophilic phosphorothioester
por: Maruyama, Hideto, et al.
Publicado: (2017)

Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers
por: Subramanian, Romesh R., et al.
Publicado: (2015)

Rational design of antisense oligonucleotides modulating the activity of TLR7/8 agonists
por: Alharbi, Arwaf S, et al.
Publicado: (2020)

Weak tension accelerates hybridization and dehybridization of short oligonucleotides
por: Hart, Derek J, et al.
Publicado: (2023)

Displacement and dissociation of oligonucleotides during DNA hairpin closure under strain
por: Ding, Fangyuan, et al.
Publicado: (2022)

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
por: Finicle, Brendan T, et al.
Publicado: (2023)

Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides
por: Wolk, Steven K., et al.
Publicado: (2015)

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle
por: Prakash, Thazha P, et al.
Publicado: (2019)

Pseudorotaxane formation via the slippage process with chemically cyclized oligonucleotides
por: Onizuka, Kazumitsu, et al.
Publicado: (2017)

Programmable manipulation of oligonucleotide–albumin interaction for elongated circulation time
por: Yang, Cai, et al.
Publicado: (2022)

Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides
por: Todisco, Marco, et al.
Publicado: (2022)

Control of backbone chemistry and chirality boost oligonucleotide splice switching activity
por: Kandasamy, Pachamuthu, et al.
Publicado: (2022)

Targeted tissue delivery of RNA therapeutics using antibody–oligonucleotide conjugates (AOCs)
por: Malecova, Barbora, et al.
Publicado: (2023)

Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates
por: Staroseletz, Yaroslav, et al.
Publicado: (2020)

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor
por: Schmidt, Karsten, et al.
Publicado: (2017)

Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation
por: Onizuka, Kazumitsu, et al.
Publicado: (2018)

Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides
por: Yoshida, Tokuyuki, et al.
Publicado: (2022)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
por: Genna, Vito, et al.
Publicado: (2023)

Delivery of oligonucleotides to bone marrow to modulate ferrochelatase splicing in a mouse model of erythropoietic protoporphyria
por: Halloy, François, et al.
Publicado: (2020)

Palmitic acid conjugation enhances potency of tricyclo-DNA splice switching oligonucleotides
por: Relizani, Karima, et al.
Publicado: (2021)

Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications
por: McGorman, Bríonna, et al.
Publicado: (2022)

Short LNA-modified oligonucleotide probes as efficient disruptors of DNA G-quadruplexes
por: Chowdhury, Souroprobho, et al.
Publicado: (2022)

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates
por: Østergaard, Michael E, et al.
Publicado: (2019)

Nucleoside alpha-thiotriphosphates, polymerases and the exonuclease III analysis of oligonucleotides containing phosphorothioate linkages
por: Yang, Zunyi, et al.
Publicado: (2007)

Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2′-O-methyl gapmer oligonucleotides
por: Valentin, Roxane, et al.
Publicado: (2021)

A strongly pairing fifth base: oligonucleotides with a C-nucleoside replacing thymidine
por: Walter, Tanja J, et al.
Publicado: (2018)

Oligonucleotides DNA containing 8-trifluoromethyl-2′-deoxyguanosine for observing Z-DNA structure
por: Bao, Hong-Liang, et al.
Publicado: (2020)

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts
por: Shin, Minwook, et al.
Publicado: (2022)

G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects
por: Wang, Feng, et al.
Publicado: (2022)

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
por: Wan, W. Brad, et al.
Publicado: (2014)

Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines
por: Linnane, Emily, et al.
Publicado: (2019)

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages
por: Duschmalé, Jörg, et al.
Publicado: (2020)

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides
por: Østergaard, Michael E, et al.
Publicado: (2020)

Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing
por: Asada, Ken, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3qbh6qa41sq8v3psit16j0aem0