Luzp4 defines a new mRNA export pathway in cancer cells

Cancer testis antigens (CTAs) represented a poorly characterized group of proteins whose expression is normally restricted to testis but are frequently up-regulated in cancer cells. Here we show that one CTA, Luzp4, is an mRNA export adaptor. It associates with the TREX mRNA export complex subunit U...

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Detalles Bibliográficos
Autores principales: Viphakone, Nicolas, Cumberbatch, Marcus G., Livingstone, Michaela J., Heath, Paul R., Dickman, Mark J., Catto, James W., Wilson, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344508/
https://www.ncbi.nlm.nih.gov/pubmed/25662211
http://dx.doi.org/10.1093/nar/gkv070
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author Viphakone, Nicolas
Cumberbatch, Marcus G.
Livingstone, Michaela J.
Heath, Paul R.
Dickman, Mark J.
Catto, James W.
Wilson, Stuart A.
author_facet Viphakone, Nicolas
Cumberbatch, Marcus G.
Livingstone, Michaela J.
Heath, Paul R.
Dickman, Mark J.
Catto, James W.
Wilson, Stuart A.
author_sort Viphakone, Nicolas
collection PubMed
description Cancer testis antigens (CTAs) represented a poorly characterized group of proteins whose expression is normally restricted to testis but are frequently up-regulated in cancer cells. Here we show that one CTA, Luzp4, is an mRNA export adaptor. It associates with the TREX mRNA export complex subunit Uap56 and harbours a Uap56 binding motif, conserved in other mRNA export adaptors. Luzp4 binds the principal mRNA export receptor Nxf1, enhances its RNA binding activity and complements Alyref knockdown in vivo. Whilst Luzp4 is up-regulated in a range of tumours, it appears preferentially expressed in melanoma cells where it is required for growth.
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spelling pubmed-43445082015-03-17 Luzp4 defines a new mRNA export pathway in cancer cells Viphakone, Nicolas Cumberbatch, Marcus G. Livingstone, Michaela J. Heath, Paul R. Dickman, Mark J. Catto, James W. Wilson, Stuart A. Nucleic Acids Res RNA Cancer testis antigens (CTAs) represented a poorly characterized group of proteins whose expression is normally restricted to testis but are frequently up-regulated in cancer cells. Here we show that one CTA, Luzp4, is an mRNA export adaptor. It associates with the TREX mRNA export complex subunit Uap56 and harbours a Uap56 binding motif, conserved in other mRNA export adaptors. Luzp4 binds the principal mRNA export receptor Nxf1, enhances its RNA binding activity and complements Alyref knockdown in vivo. Whilst Luzp4 is up-regulated in a range of tumours, it appears preferentially expressed in melanoma cells where it is required for growth. Oxford University Press 2015-02-27 2015-02-06 /pmc/articles/PMC4344508/ /pubmed/25662211 http://dx.doi.org/10.1093/nar/gkv070 Text en © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle RNA
Viphakone, Nicolas
Cumberbatch, Marcus G.
Livingstone, Michaela J.
Heath, Paul R.
Dickman, Mark J.
Catto, James W.
Wilson, Stuart A.
Luzp4 defines a new mRNA export pathway in cancer cells
title Luzp4 defines a new mRNA export pathway in cancer cells
title_full Luzp4 defines a new mRNA export pathway in cancer cells
title_fullStr Luzp4 defines a new mRNA export pathway in cancer cells
title_full_unstemmed Luzp4 defines a new mRNA export pathway in cancer cells
title_short Luzp4 defines a new mRNA export pathway in cancer cells
title_sort luzp4 defines a new mrna export pathway in cancer cells
topic RNA
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344508/
https://www.ncbi.nlm.nih.gov/pubmed/25662211
http://dx.doi.org/10.1093/nar/gkv070
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