Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis

HIV-1 reverse transcriptase (RT) connection subdomain mutations at positions 348, 369 and 376 have been associated with resistance to non-nucleoside RT inhibitors (NNRTIs). N348I may interfere with the initiation of (+)-strand DNA synthesis by reducing polypurine tract (PPT) removal in the presence...

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Detalles Bibliográficos
Autores principales: Betancor, Gilberto, Álvarez, Mar, Marcelli, Barbara, Andrés, Cristina, Martínez, Miguel A., Menéndez-Arias, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344514/
https://www.ncbi.nlm.nih.gov/pubmed/25662223
http://dx.doi.org/10.1093/nar/gkv077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344514/
https://www.ncbi.nlm.nih.gov/pubmed/25662223
http://dx.doi.org/10.1093/nar/gkv077

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