Complementation of aprataxin deficiency by base excision repair enzymes

Abortive ligation during base excision repair (BER) leads to blocked repair intermediates containing a 5′-adenylated-deoxyribose phosphate (5′-AMP-dRP) group. Aprataxin (APTX) is able to remove the AMP group allowing repair to proceed. Earlier results had indicated that purified DNA polymerase β (po...

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Detalles Bibliográficos
Autores principales: Çağlayan, Melike, Horton, Julie K., Prasad, Rajendra, Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344515/
https://www.ncbi.nlm.nih.gov/pubmed/25662216
http://dx.doi.org/10.1093/nar/gkv079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344515/
https://www.ncbi.nlm.nih.gov/pubmed/25662216
http://dx.doi.org/10.1093/nar/gkv079

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