Cargando…

Synthesis and Biological Evaluation of Carbocyclic Analogues of Pachastrissamine

A series of carbocyclic analogues of naturally-occurring marine sphingolipid pachastrissamine were prepared and biologically evaluated. The analogues were efficiently synthesized via a tandem enyne/diene-ene metathesis reaction as a key step. We found that the analogue 4b exhibited comparable cytoto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kwon, Yongseok, Song, Jayoung, Bae, Hoon, Kim, Woo-Jung, Lee, Joo-Youn, Han, Geun-Hee, Lee, Sang Kook, Kim, Sanghee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344604/ https://www.ncbi.nlm.nih.gov/pubmed/25654428 http://dx.doi.org/10.3390/md13020824

Ejemplares similares

Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
por: Matyugina, E.S., et al.
Publicado: (2012)

Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives
por: Hasaneen, Noha, et al.
Publicado: (2019)

Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ(0))
por: Llona-Minguez, Sabin, et al.
Publicado: (2014)

Revaluation of biomass-derived furfuryl alcohol derivatives for the synthesis of carbocyclic nucleoside phosphonate analogues
por: Sidi Mohamed, Bemba, et al.
Publicado: (2017)

Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine
por: De Clercq, Erik, et al.
Publicado: (1990)

All-round catalytic and atroposelective strategy via dynamic kinetic resolution for N-/2-/3-arylindoles
por: Kim, Ahreum, et al.
Publicado: (2023)

Epigenetic Anti‐Cancer Treatment With a Stabilized Carbocyclic Decitabine Analogue
por: Traube, Franziska R., et al.
Publicado: (2022)

9‐Membered Carbocycles: Strategies and Tactics for their Synthesis
por: Huber, Tatjana, et al.
Publicado: (2018)

Synthesis of a Novel Carbocyclic Analog of Bredinin
por: Nair, Vasu, et al.
Publicado: (2013)

Catalytic asymmetric synthesis of carbocyclic C-nucleosides
por: Mishra, Sourabh, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of BODIPY-PF-543
por: Shrestha, Jitendra, et al.
Publicado: (2019)

The first intermolecular interrupted imino-Nazarov reaction: expeditious access to carbocyclic nucleoside analogues
por: William, Ronny, et al.
Publicado: (2016)

Enantiomerically Pure Phosphonated Carbocyclic 2'-Oxa-3'-Azanucleosides: Synthesis and Biological Evaluation
por: Romeo, Roberto, et al.
Publicado: (2014)

Synthesis and Conformational Analysis of Locked Carbocyclic Analogues of 1,3-Diazepinone Riboside, a High-Affinity Cytidine Deaminase Inhibitor
por: Ludek, Olaf R., et al.
Publicado: (2009)

Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin
por: Toti, Kiran S., et al.
Publicado: (2022)

Alkynyl Prins carbocyclization cascades for the synthesis of linear-fused heterocyclic ring systems
por: Hernandez, Jackson J., et al.
Publicado: (2022)

Palladium-Catalyzed Oxidative Acyloxylation/Carbocyclization of Allenynes**
por: Deng, Youqian, et al.
Publicado: (2013)

Curcumin and Its Carbocyclic Analogs: Structure-Activity in Relation to Antioxidant and Selected Biological Properties
por: Bhullar, Khushwant S., et al.
Publicado: (2013)

Catalytic enantioselective synthesis of carbocyclic and heterocyclic spiranes via a decarboxylative aldol cyclization
por: Inanaga, Kazato, et al.
Publicado: (2020)

Synthesis of Vicinal Carbocycles by Intramolecular Nickel-Catalyzed Conjunctive Cross-Electrophile Coupling Reaction
por: Hewitt, Kirsten A., et al.
Publicado: (2022)

Synthesis of 4′-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents
por: Biteau, Nicolas G., et al.
Publicado: (2023)

Design, synthesis, and evaluation of curcumin analogues as potential inhibitors of bacterial sialidase
por: Kim, Bo Ram, et al.
Publicado: (2018)

Palladium‐Catalyzed Oxidative Carbocyclization–Borylation of Enallenes to Cyclobutenes
por: Qiu, Youai, et al.
Publicado: (2016)

Palladium-Catalyzed Oxidative Domino Carbocyclization–Arylation of Bisallenes
por: Volla, Chandra M. R., et al.
Publicado: (2016)

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases
por: Heckenbichler, Kathrin, et al.
Publicado: (2018)

Efficient Palladium‐Catalyzed Aerobic Arylative Carbocyclization of Enallenynes
por: Liu, Jie, et al.
Publicado: (2018)

Allylic Carbocyclic Inhibitors Covalently Bind Glycoside Hydrolases
por: Grayfer, Tatyana D., et al.
Publicado: (2023)

Cobalt-assisted route to rare carbocyclic C-ribonucleosides
por: Ojeda-Porras, A. C., et al.
Publicado: (2023)

Photocatalyzed Dowd–Beckwith radical-polar crossover reaction for the synthesis of medium-sized carbocyclic compounds
por: Singha, Tushar, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition
por: Kwon, Do-Yeon, et al.
Publicado: (2015)

Synthesis of Highly Oxygenated Carbocycles by Stereoselective Coupling of Alkynes to 1,3- and 1,4-Dicarbonyl Systems
por: Kier, Matthew J., et al.
Publicado: (2017)

Control of Selectivity in Palladium-Catalyzed Oxidative Carbocyclization/Borylation of Allenynes**
por: Deng, Youqian, et al.
Publicado: (2013)

Palladium-Catalyzed Oxidative Regio- and Diastereoselective Diarylating Carbocyclization of Dienynes
por: Jiang, Min, et al.
Publicado: (2013)

Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment
por: Godesi, Sreenivasulu, et al.
Publicado: (2023)

Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity
por: Kim, Su Bin, et al.
Publicado: (2020)

Tenofovir disoproxil fumarate monotherapy for nucleos(t)ide analogue-naïve and nucleos(t)ide analogue-experienced chronic hepatitis B patients
por: Jung, Sang Kyung, et al.
Publicado: (2015)

Anticancer Effects of High Glucosinolate Synthesis Lines of Brassica rapa on Colorectal Cancer Cells
por: Kim, Jung Sun, et al.
Publicado: (2022)

Syntheses of Isoxazoline-Carbocyclic Nucleosides and Their Antiviral Evaluation: A Standard Protocol
por: Quadrelli, Paolo, et al.
Publicado: (2014)

Efficient Palladium‐Catalyzed Aerobic Oxidative Carbocyclization to Seven‐Membered Heterocycles
por: Liu, Jie, et al.
Publicado: (2020)

Stability of Carbocyclic Phosphinyl Radicals: Effect of Ring Size, Delocalization, and Sterics
por: Ott, Anna, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ae9oj7fhr3pp5634prpfa8mprt