The Chemically Synthesized Ageladine A-Derivative LysoGlow84 Stains Lysosomes in Viable Mammalian Brain Cells and Specific Structures in the Marine Flatworm Macrostomum lignano

Based on the chemical structure and the known chemical synthesis of the marine sponge alkaloid ageladine A, we synthesized the ageladine A-derivative 4-(naphthalene-2-yl)-1H-imidazo[4,5-c]pyridine trifluoroacetate (LysoGlow84). The two-step synthesis started with the Pictet-Spengler reaction of hist...

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Detalles Bibliográficos
Autores principales: Mordhorst, Thorsten, Awal, Sushil, Jordan, Sebastian, Petters, Charlotte, Sartoris, Linda, Dringen, Ralf, Bickmeyer, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344609/
https://www.ncbi.nlm.nih.gov/pubmed/25679913
http://dx.doi.org/10.3390/md13020920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344609/
https://www.ncbi.nlm.nih.gov/pubmed/25679913
http://dx.doi.org/10.3390/md13020920

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