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Selective Blocking Effects of 4,9-Anhydrotetrodotoxin, Purified from a Crude Mixture of Tetrodotoxin Analogues, on Na(V)1.6 Channels and Its Chemical Aspects
Tetrodotoxin (TTX) is a potent neurotoxin found in a number of marine creatures including the pufferfish, where it is synthesized by bacteria and accumulated through the food chain. It is a potent and selective blocker of some types of voltage-gated Na(+) channel (Na(V) channel). 4,9-Anhydrotetrodot...
Autores principales: | Teramoto, Noriyoshi, Yotsu-Yamashita, Mari |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344613/ https://www.ncbi.nlm.nih.gov/pubmed/25686275 http://dx.doi.org/10.3390/md13020984 |
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