The Pore-Forming α-Toxin from Clostridium septicum Activates the MAPK Pathway in a Ras-c-Raf-Dependent and Independent Manner

Clostridium septicum is the causative agent of atraumatic gas gangrene, with α-toxin, an extracellular pore-forming toxin, essential for disease. How C. septicum modulates the host’s innate immune response is poorly defined, although α-toxin-intoxicated muscle cells undergo cellular oncosis, charact...

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Detalles Bibliográficos
Autores principales: Chakravorty, Anjana, Awad, Milena M., Cheung, Jackie K., Hiscox, Thomas J., Lyras, Dena, Rood, Julian I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344638/
https://www.ncbi.nlm.nih.gov/pubmed/25675415
http://dx.doi.org/10.3390/toxins7020516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344638/
https://www.ncbi.nlm.nih.gov/pubmed/25675415
http://dx.doi.org/10.3390/toxins7020516

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