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ATG12-ATG3 Interacts with Alix to Promote Basal Autophagic Flux and Late Endosome Function
The ubiquitin-like molecule ATG12 is required for the early steps of autophagy. Recently, we identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an ATG12 conjugation target. Here, we demonstrate that cells lacking ATG12-ATG3 have impaired basal autophagic flux, accum...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344874/ https://www.ncbi.nlm.nih.gov/pubmed/25686249 http://dx.doi.org/10.1038/ncb3112 |