In Silico Design of Human IMPDH Inhibitors Using Pharmacophore Mapping and Molecular Docking Approaches

Inosine 5′-monophosphate dehydrogenase (IMPDH) is one of the crucial enzymes in the de novo biosynthesis of guanosine nucleotides. It has served as an attractive target in immunosuppressive, anticancer, antiviral, and antiparasitic therapeutic strategies. In this study, pharmacophore mapping and mol...

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Detalles Bibliográficos
Autores principales: Li, Rui-Juan, Wang, Ya-Li, Wang, Qing-He, Wang, Jian, Cheng, Mao-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345060/
https://www.ncbi.nlm.nih.gov/pubmed/25784957
http://dx.doi.org/10.1155/2015/418767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345060/
https://www.ncbi.nlm.nih.gov/pubmed/25784957
http://dx.doi.org/10.1155/2015/418767

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