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Nutrient-stimulated insulin secretion in mouse islets is critically dependent on intracellular pH

BACKGROUND: Many mechanistic steps underlying nutrient-stimulated insulin secretion (NSIS) are poorly understood. The influence of intracellular pH (pH(i)) on insulin secretion is widely documented, and can be used as an investigative tool. This study demonstrates previously unknown effects of pH(i)...

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Detalles Bibliográficos
Autores principales: Gunawardana, Subhadra C, Rocheleau, Jonathan V, Head, W Steven, Piston, David W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC434517/
https://www.ncbi.nlm.nih.gov/pubmed/15193158
http://dx.doi.org/10.1186/1472-6823-4-1