Rational design of new NO and redox sensitivity into connexin26 hemichannels

CO(2) directly opens hemichannels of connexin26 (Cx26) by carbamylating K125, thereby allowing salt bridge formation with R104 of the neighbouring subunit in the connexin hexamer. The formation of the inter-subunit carbamate bridges within the hexameric hemichannel traps it in the open state. Here,...

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Detalles Bibliográficos
Autores principales: Meigh, Louise, Cook, Daniel, Zhang, Jie, Dale, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345282/
https://www.ncbi.nlm.nih.gov/pubmed/25673329
http://dx.doi.org/10.1098/rsob.140208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345282/
https://www.ncbi.nlm.nih.gov/pubmed/25673329
http://dx.doi.org/10.1098/rsob.140208

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