Histone-targeted Polyplexes Avoid Endosomal Escape and Enter the Nucleus During Postmitotic Redistribution of ER Membranes

Nonviral gene delivery is a promising therapeutic approach because of its safety and controllability, yet limited gene transfer efficacy is a common issue. Most nonviral strategies rely upon endosomal escape designs; however, endosomal escape is often uncorrelated with improved gene transfer and mem...

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Detalles Bibliográficos
Autores principales: Ross, Nikki L, Munsell, Erik V, Sabanayagam, Chandran, Sullivan, Millicent O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345312/
https://www.ncbi.nlm.nih.gov/pubmed/25668340
http://dx.doi.org/10.1038/mtna.2015.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345312/
https://www.ncbi.nlm.nih.gov/pubmed/25668340
http://dx.doi.org/10.1038/mtna.2015.2

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