GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3′-oxime inhibit microRNA maturation in mouse embryonic stem cells

Wnt/β-catenin signalling plays a prominent role in maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs). microRNAs (miRNAs) have critical roles in maintaining pluripotency and directing reprogramming. To investigate the effect of GSK3 inhibitors on miRNA expression, we ana...

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Detalles Bibliográficos
Autores principales: Wu, Yongyan, Liu, Fayang, Liu, Yingying, Liu, Xiaolei, Ai, Zhiying, Guo, Zekun, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345320/
https://www.ncbi.nlm.nih.gov/pubmed/25727520
http://dx.doi.org/10.1038/srep08666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345320/
https://www.ncbi.nlm.nih.gov/pubmed/25727520
http://dx.doi.org/10.1038/srep08666

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