Cargando…

Elevated germline mutation rate in teenage fathers

Men age and die, while cells in their germline are programmed to be immortal. To elucidate how germ cells maintain viable DNA despite increasing parental age, we analysed DNA from 24 097 parents and their children, from Europe, the Middle East and Africa. We chose repetitive microsatellite DNA that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Forster, Peter, Hohoff, Carsten, Dunkelmann, Bettina, Schürenkamp, Marianne, Pfeiffer, Heidi, Neuhuber, Franz, Brinkmann, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345458/ https://www.ncbi.nlm.nih.gov/pubmed/25694621 http://dx.doi.org/10.1098/rspb.2014.2898

Ejemplares similares

Germline mutation rate is elevated in young and old parents in Caenorhabditis remanei
por: Chen, Hwei-yen, et al.
Publicado: (2023)

Acute myeloid leukemia in a father and son with a germline mutation of ASXL1
por: Seiter, Karen, et al.
Publicado: (2018)

Rate of de novo mutations, father’s age, and disease risk
por: Kong, Augustine, et al.
Publicado: (2012)

Mutation rates and the evolution of germline structure
por: Scally, Aylwyn
Publicado: (2016)

Timing, rates and spectra of human germline mutation
por: Rahbari, Raheleh, et al.
Publicado: (2015)

Contrasting Determinants of Mutation Rates in Germline and Soma
por: Chen, Chen, et al.
Publicado: (2017)

Mutation-rate plasticity and the germline of unicellular organisms
por: Aanen, Duur K., et al.
Publicado: (2019)

Evolution of the germline mutation rate across vertebrates
por: Bergeron, Lucie A., et al.
Publicado: (2023)

Idiopathic elevated episcleral venous pressure in a teenager
por: Sun, Catherine Q., et al.
Publicado: (2020)

Sexual selection, germline mutation rate and sperm competition
por: Møller, AP, et al.
Publicado: (2003)

Direct estimate of the rate of germline mutation in a bird
por: Smeds, Linnéa, et al.
Publicado: (2016)

Detection of germline mosaicism in fathers of children with intellectual disability syndromes caused by de novo variants
por: Frisk, Sofia, et al.
Publicado: (2022)

Retroviral integrations contribute to elevated host cancer rates during germline invasion
por: McEwen, Gayle K., et al.
Publicado: (2021)

Differences between germline and somatic mutation rates in humans and mice
por: Milholland, Brandon, et al.
Publicado: (2017)

Examining the Effects of Hibernation on Germline Mutation Rates in Grizzly Bears
por: Wang, Richard J, et al.
Publicado: (2022)

Mutation analysis for newly suggested 30 Y-STR loci with high mutation rates in Chinese father-son pairs
por: Wang, Fei, et al.
Publicado: (2022)

Germline de novo mutation rates on exons versus introns in humans
por: Rodriguez-Galindo, Miguel, et al.
Publicado: (2020)

Germline mutation rates in young adults predict longevity and reproductive lifespan
por: Cawthon, Richard M., et al.
Publicado: (2020)

Sequence variants affecting the genome-wide rate of germline microsatellite mutations
por: Kristmundsdottir, Snaedis, et al.
Publicado: (2023)

Father
por: Wilcox, Ella Wheeler
Publicado: (1915)

Germline Mutation in RNASEL Predicts Increased Risk of Head and Neck, Uterine Cervix and Breast Cancer
por: Madsen, Bo Eskerod, et al.
Publicado: (2008)

Teenagers /
por: Lewis, Gordon
Publicado: (2007)

Single genome retrieval of context-dependent variability in mutation rates for human germline
por: Sahakyan, Aleksandr B., et al.
Publicado: (2017)

Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans
por: Carlson, Jedidiah, et al.
Publicado: (2018)

Low Base-Substitution Mutation Rate in the Germline Genome of the Ciliate Tetrahymena thermophila
por: Long, Hongan, et al.
Publicado: (2016)

The Impact of DNA Methylation Dynamics on the Mutation Rate During Human Germline Development
por: Zhou, Yijia, et al.
Publicado: (2020)

Experimental estimates of germline mutation rate in eukaryotes: a phylogenetic meta-analysis
por: Wang, Yiguan, et al.
Publicado: (2023)

Father 2 Son: The Impact of African American Father–Son Sexual Communication on African American Adolescent Sons’ Sexual Behaviors
por: Harris, Allyssa L., et al.
Publicado: (2018)

Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population
por: Yao, Jianfei, et al.
Publicado: (2022)

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice
por: Uchimura, Arikuni, et al.
Publicado: (2015)

Haplotypic polymorphisms and mutation rate estimates of 22 Y-chromosome STRs in the Northern Chinese Han father–son pairs
por: Yang, Yaran, et al.
Publicado: (2018)

The Mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates
por: Bergeron, Lucie A, et al.
Publicado: (2022)

Evidence of Site-Specific and Male-Biased Germline Mutation Rate in a Wild Songbird
por: Zhang, Hongkai, et al.
Publicado: (2023)

Fathers and sons /
por: Turgenev, Ivan Sergeevich, 1818-1883
Publicado: (1962)

The apostolic fathers
Publicado: (1912)

Father figures
por: Jobling, Mark A
Publicado: (2011)

Fathers and sons
por: Turgenev, Ivan Sergeevich, 1818-1883

Father Damien
Publicado: (1889)

Neglected Fathers
Publicado: (1958)

The Father's Responsibilities
Publicado: (1920)

Cannot write session to /tmp/vufind_sessions/sess_p6e9sook5qrg9afaauc8524uob